Longer Telomere Length of T lymphocytes in Patients with Early and Chronic Psychosis
Young-Chul Chung 1, 2*, Yin Cui 1, 2, Vishwanath Vasudev Prabhu 1, 2, Thong Ba Nguyen 1, 2, Subramaniam Mohana Devi 1, 2
1Department of Psychiatry, Chonbuk National University Medical School, 2Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital
Received: November 6, 2016; Revised: November 30, 2016; Accepted: November 30, 2016; Published online: November 30, 2016.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: To investigate pathological conditions that act as sources of pro-inflammatory cytokines and cytotoxic substances to examine TL in patients with either early (DI ≤ 5 years) or chronic (DI > 5 years) psychosis using T lymphocytes. Methods: Based on these factors and the important role that T lymphocytes play in inflammation, the present study measured the TL of T lymphocytes in patients with either early or chronic psychosis. Additionally, smoking, metabolic syndrome, depression, and cognitive functioning were assessed to control for confounding effects. Results: TL was significantly longer in patients with early and chronic psychosis than in healthy control subjects and, moreover, the significance of these findings remained after controlling for various confounding factors.
Conclusion: Possible mechanisms underlying the effects of antipsychotic medications on telomerase are discussed in the present study, but further studies measuring both telomerase activity and TL using a prospective design will be required.
Keywords: Antipsychotics, Telomere length, Telomerase, T lymphocytes, Psychosis, Quantitative Real-time PCR


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