EVALUATION OF OXIDANT/ANTIOXIDANT STATUS AND CYTOKINE LEVELS IN PATIENTS WITH CANNABIS USE DISORDER
H?seyin Bayazıt 1*, Salih Selek 2, Ibrahim Fatih Karababa 3, Erdinc Cicek 4, Nurten Aksoy 5
1Siverek State Hospital, Department of Psychiatry, Sanliurfa, Turkey, 2Harris County Psychiatric Center, University of Texas Health Science Center at Houston, Tx USA, 3Department of Psychiatry, Faculty of Medicine, University of Harran, Sanliurfa, Turkey, 4Department of Psychiatry, ?umra State Hospital, Konya, Turkey, 5Department of Clinical Biochemistry, Faculty of Medicine, University of Harran, Sanliurfa, Turkey
Received: July 14, 2016; Revised: September 4, 2016; Accepted: September 11, 2016; Published online: September 11, 2016.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: Cannabis is the most commonly used illegal drug in the world and it has too much adverse effect. In this study, we aimed to evaluate oxidant, anti-oxidant status and cytokine levels in individuals with cannabis use disorder.
Methods: Thirty-four patients with cannabis use disorder and 34 healthy controls were enrolled to the study. Serum total antioxidant status, total oxidant status and cytokine levels were investigated in patients with cannabis use disorder and healthy controls.
Results: We found increased levels of Total Oxidant Status, Oxidative Stress Index and IL-1β, IL-6, IL-8 and TNF-α in individuals with cannabis dependency compared to healthy people. When we compare Total Antioxidant Status, IL-12 and IFN- γ levels, there were no differences in both groups. There was positive correlation between IL-6 and Total Oxidant Status, Oxidative Stress Index levels.
Conclusion: The oxidative balance of individuals with cannabis use disorder was impaired and they had higher levels of IL-1β, IL-6, IL-8 and TNF-α, which is a pro-inflammatory cytokine and indicates increased inflammation compared to healthy controls. Thus, these findings suggest that cannabis increased inflammation and impaired the oxidative balance.
Keywords: cannabis, oxidants, antioxidants, cytokines, Interleukin-6, Interleukin-8, Interleukin-1beta, tumor necrosis factor-alpha


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