Limbic Encephalitis Manifesting as Selective Amnesia and Seizure-Like Activity: A Case Report
So-Yeon Kim 1, Yoo Hyun Um 1, Sung Chul Lim 2, Jong-Hyun Jeong 1*
1Department of Psychiatry, College of Medicine, The Catholic University of Korea, 2Department of Neurology, College of Medicine, The Catholic University of Korea
Received: June 22, 2016; Revised: July 18, 2016; Accepted: July 26, 2016; Published online: July 26, 2016.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histopathological evidence of medial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI-1) is an auto-antigen associated with LE. We report a 37-year-old male patient with LGI-1-related limbic encephalitis who presented with recurrent episodes of selective amnesia, seizure-like activity, confusion, and personality change. His symptoms were significantly improved with steroid therapy. Thorough differential diagnosis with consideration for autoimmune encephalitis should be in patients with presentation of symptoms, such as memory impairment, personality change and seizure-like activity, especially when other neurological diagnoses are excluded.
Keywords: Anti-LGI-1 antibody encephalitis, Neuropsychiatric symptoms, Steroid therapy


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