Effect of Maternal Depression on Brain-DerivedNeurotrophic Factor Levels in Fetal Cord Blood
Erdem ?nder S?nmez 1*, Faruk U?uz 2, Mine ?ahing?z 2, Nazmiye Kaya 2, Mehmet Akif Camkurt 3, G?ls?m S?nmez 4, Zeynel G?kmen 5, Mustafa Ba?aran 6, Kazım Gezgin? 7, Sami Sait Erdem 8, Hasan Haluk D?lger 9, Erkan Ta?y?rek 9
1Adana Ekrem Tok, Mental Health Hospital, Adana, Turkey, 2Necmettin Erbakan University, Psychiatry Department, Konya, Turkey, 3Af?in State Hospital, Psychiatry Department, Af?in, Kahramanmara?, 4?ukurova University, Department of Pediatrics, Adana Turkey, 5Konya Research and Training Hospital, Neonatology Department, Konya, Turkey, 6Konya Research and Training Hospital, Department of Obstetrics and Gynecology, Konya, Turkey, 7Meram Faculty of Medicine, Necmettin Erbakan University, Department of Obstetrics and Gynecology, Konya, Turkey, 8Konya Research and Training Hospital, Department of Biochemistry, Konya, Turkey, 9 Meram Faculty of Medicine, Necmettin Erbakan University, Department of Biochemistry, Konya, Turkey
Received: April 8, 2016; Revised: May 27, 2016; Accepted: June 16, 2016; Published online: June 16, 2016.
© The Korean College of Neuropsychopharmacology. All rights reserved.

OBJECTIVE: We aimed to assess the association between cord blood Brain-Derived Neurotrophic Factor (BDNF) concentration and maternal depression during pregnancy.
METHOD: A total of 48 pregnant women admitted for elective caesarean section to The Konya Research and Training Hospital and Konya Necmettin Erbakan University Meram Medical Faculty, department of Obstetrics and Gynecology were included in this study. The study group included 23 women diagnosed as having depression during pregnancy and the control group included 25 pregnant women who did not experience depression during pregnancy.
RESULTS: The groups had similar sociodemographic characteristics.
Cord blood BDNF concentration was significantly lower in babies born to mothers with major depression as compared with those in the control group, means were 0.98 and 2.08 respectively, p<0.001. We didn’t find any correlation between the umbilical cord blood BDNF levels and BDI scores.
CONCLUSION: The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels.
Keywords: Brain-derived neurotrophic factor, Pregnancy, Depression, Fetal cord blood, Neurodevelopment