Baclofen Abuse due to its hypomanic effect in patients with Alcohol Dependence and co morbid Major Depressive Disorder
Soumitra Ghosh , Dhrubajyoti Bhuyan *
Assam Medical College & Hospital, Dibrugarh, Assam, India
Received: March 17, 2016; Revised: May 18, 2016; Accepted: May 18, 2016; Published online: May 18, 2016.
© The Korean College of Neuropsychopharmacology. All rights reserved.

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Abstract
Introduction:
Baclofen is a gamma ? aminobutyric acid type B receptor agonist used as an anticraving agent for treatment of Alcohol Dependence. It has gained popularity in the recent times because it is well tolerated even in patients with hepatic impairments.
Objective: To summaries the latest literature about baclofen induced hypomania and report a case of baclofen abuse because of its mood elevating property in a patients of Alcohol Dependence with co-morbid Major Depressive Disorder
Methods: Literature review and Case study of a 36 year old male with alcohol dependence with co morbid major depressive disorder was prescribed with Tablet Baclofen as an anticraving agent along with antidepressant medicines.
Results and Observation: The patients who did not improve with conventional antidepressant therapy started feeling better in terms of his mood symptoms on taking tab Baclofen. Owing to the mood elevating property he started abusing Baclofen
Discussion and Conclusion: Despite its safety profile in hepatic impairment, one must be very cautious in prescribing Baclofen because of its mood altering property which may account for its abuse potentiality
Keywords: Baclofen, Alcohol Use Disorder, Resistant Depression, Abuse


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