The Biomarker Potential of Malondialdehyde, Superoxide Dismutase and Catalase Activity in Drug Na?ve, First Episode, Non-Smoker Generalized Anxiety Disorder Patients
Ebru Fındıklı 1, Mehmet Akif Camkurt 2*, Mehmet Fatih Karaaslan 1, Erg?l Belge Kuruta? 3, H?seyin Avni Fındıklı 4, Filiz ?zci 5, Perihan S?mer 3
1Kahramanmara? S?t?? ?mam University, Psychiatry Department, 2Af?in State Hospital, Psychiatry Department, Af?in, Kahramanmara?, 3Kahramanmara? S?t?? ?mam University, Biochemistry Department, 4Adıyaman University, School of Medicine, Internal Medicine, 5?stanbul Bilim University, Psychiatry Department
Received: March 8, 2016; Revised: April 13, 2016; Accepted: April 18, 2016; Published online: April 18, 2016.
© The Korean College of Neuropsychopharmacology. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Generalized anxiety disorder (GAD) is a common anxiety disorder. Although lots of research done to reveal neurobiological basis of GAD, it is still unclear. Diagnosis of GAD depends on subjective complaints of patients, thus the need for a biological marker emerged. In this study, we aimed to investigate diagnostic value of malondialdehyde(MDA), superoxide dismutase(SOD) and catalase(CAT) in GAD.
We evaluated MDA, SOD and CAT levels in peripheral blood of 46 patients and 45 controls. MDA was measured with Ohkawa's methods, SOD was measured with Fridovich method and CAT was measured with Beutler's method.
MDA was significantly increased in patients than controls, medians 4.05 nmol/mg and 1.71 nmol/mg respectively, p<0.001, SOD and CAT activity was significantly decreased in patients than controls, medians of SOD were 159.07U/mg and 301.87U/mg, p<0.001 respectively, medians for CAT were 138.47U/mg and 160.60U/mg respectively. We found high correlation between Hamilton Anxiety Scale(Ham-A) and SOD, MDA r values were 0.723 and 0.715 respectively, p<0.001 for both. ROC curve analysis showed high diagnostic performance for MDA and SOD, low diagnostic performance for CAT, areas under curve were 1.0, 1.0 and 0.648 respectively.
Our results reveal possible diagnostic value of MDA but not SOD and CAT. Future studies should investigate diagnostic value of oxidants and antioxidantn enzymes in larger samples and include diagnostic value of these parameters.
Keywords: Malondialdehyde, Superoxide Dismutase, Catalase, Generalised Anxiety Disorder, Diagnostic, Oxidative, Antioxidant, Biomarker


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