Investigation of Relaxin-3 Serum Levels in Terms of Social Interaction, Communication, and Appetite as a Biomarker in Children with Autism
Semih Erden *, Kevser Nalbant , İbrahim Kılınç
Necmettin Erbakan University, Child and Adolescent Psychiatry
Received: December 10, 2020; Revised: April 3, 2021; Accepted: April 5, 2021; Published online: April 5, 2021.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: The aim of this study was to investigate the possible relationship between relaxin-3 and ASD.
Methods: Serum relaxin-3 was measured in 80 children (50 children diagnosed with ASD and 30 healthy controls). Symptom severity in the ASD group was evaluated by the Childhood Autism Rating Scale. Behavioral and nutritional problems in the groups were evaluated with the Abnormal Behavior Checklist and the Children's Eating Behavior Questionnaire.
Results: Our findings found that serum relaxin-3 levels were higher in children with ASD than in the healthy controls. The listening response sub-scale score of the CARS scale was found to increase as the level of relaxin-3 increased. However, as relaxin-3 levels increased in children with ASD, it was found that the speech problem sub-scale score on the ABC scale and the desire to drink score on the CEBQ scale increased, but the satiety responsiveness and food fussiness scores decreased.
Conclusion: This study the first to investigate serum levels of relaxin-3, which has a role in regulating social behavior and nutritional behavior in children with ASD
Keywords: autism, communication, appetite, relaxin-3


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