Apathy: Neurobiology, Assessment and Treatment.
Mario Fahed 1*, David C. Steffens 1
Department of Psychiatry, University of Connecticut, School of Medicine
Received: February 20, 2021; Revised: March 9, 2021; Accepted: March 9, 2021; Published online: March 9, 2021.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Apathy is a highly prevalent, disabling and treatment resistant syndrome. It is defined as a quantitative reduction of goal-directed activity in comparison to the patient’s previous level of in multiple dimensions including behavior/cognition, emotion and social interaction. It has been described in major depressive disorder, Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease, cerebrovascular disease, and vascular dementia, among others. This review will address the neuropsychology and associated neurobiological underpinnings of apathy in the above conditions, identify specific methods to assess apathy clinically, and review the literature on managing apathy across these various disorders.
Keywords: apathy, amotivation, anhedonia