Acute hepatitis due to agomelatine use in older women with depression— a case series

Cheng-Chen Chang ^{1, 2}, Yen-Jen Chen ¹, Yu-An Chen ¹, Yi-Cheng Liao ^1*

¹Department of Psychiatry, Changhua Christian Hospital, Changhua, Taiwan, ²School of Medicine, Chung Shan Medical University, Taichung, Taiwan

Received: December 7, 2020; Revised: January 31, 2021; Accepted: February 1, 2021; Published online: February 1, 2021.

Abstract: Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 elderly female cases with acute hepatitis occurring due to highly probable idiosyncratic drug-induced liver injury caused by agomelatine. From these cases, regular surveillance on liver function in the elderly women taking antidepressants would be of benefits.; Keywords: agomelatine, acute hepatitis, major depression

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