Neutrophil-lymphocyte and platelet-lymphocyte ratios among adolescents with substance use disorder: A preliminary study
SERDAR KARATOPRAK 1*, Necati Uzun 2, Mehmet Akif Akıncı 3, Yunus Emre Donmez 4
1Department of Child and Adolescent Psychiatry, Elazıg Fethi Sekin City Hospital, 2Department of Child and Adolescent Psychiatry, Meram School of Medicine, Necmettin Erbakan University, 3Department of Child and Adolescent Psychiatry, Dr. Ali Kemal Belviranlı Maternity and Children’s Hospital, 4Department of Child and Adolescent Psychiatry, School of Medicine, Inonu University
Received: August 10, 2020; Revised: November 4, 2020; Accepted: November 9, 2020; Published online: November 9, 2020.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Objective: Substance use disorder (SUD) is a serious public health problem affecting both the individual and the society, and substance use-related deaths and disability have been shown to increase gradually. Recent etiologic studies have reported that there is an relation between inflammatory parameters and psychiatric disorders. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) used as an indicator of inflammation have been shown to be increased in various pyschiatric disorders. In this study, we aimed to investigate the NLR and PLR levels in adolescets with SUD.
Methods: This study was conducted by retrospectively examining the records of 55 male adolescents who were followed up with SUD in a child and adolescent psychiatry outpatient clinic between November 2019-June 2020. Patients who had comorbid psychiatric disorder were included, and those who received any psychotropic medication were excluded. A total of 61 healthy male adolescents in the same age range without any psychiatric disorders were recruited as a control group. Neutrophil-lymphocyte-platelet counts were noted retrospectively from complete blood tests, and NLR-PLR were calculated.
Results: The NLR and PLR levels of adolescents with SUD were significantly higher than the healthy adolescents (p<0.01, p<0.05, respectively). In addition, conduct disorder, depression, and attention deficit/hyperactivity disorder, which were determined as the most common comorbid psychiatric disorders had no effects on NLR (p=0.29, p=0.37, p=0.63, respectively) and PLR (p=0.53, p=0.69, p=0.36, respectively) levels.
Conclusion: The results of current study indicate that inflammatory processes may have a key role in the pathophysiology of SUD.
Keywords: Substance Use Disorder, Inflammation, Neutrophil-lymphocyte ratio, Platelet-lymphocyte ratio, Adolescents