Methyl jasmonate: behavioral and molecular implications in neurological disorders
Oritoke Modupe Aluko 1, 2, 3*, Joy Iroegbu 2, Omamuyovwi Ijomone 2, Solomon Umukoro 3
1Department of Physiology, Federal University of Technology, Akure, Nigeria, 2The NeuroLab, Federal University of Technology, Akure, Nigeria, 3Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria
Received: July 20, 2020; Revised: October 27, 2020; Accepted: October 28, 2020; Published online: October 28, 2020.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Methyl jasmonate (MJ) is a derivative of the jasmonate family which is found in most tropical regions of the world and present in many fruits and vegetables such as grapevines, tomato, rice, and sugarcane. MJ is a cyclopentanone phytohormone that plays a vital role in defense against stress and pathogens in plants. This has led to its isolation from plants and study in animals. Many of these studies have been carried out to evaluate its therapeutic effects on behavioral and neurochemical functions. It has however been proposed to have beneficial potential over a wide range of neurological disorders. Hence, the aim to review the neuroprotective properties of MJ and its probable mechanisms of ameliorating neurological disorders.
The information used for this review was sourced from research articles and scientific databases using ‘methyl jasmonate’, ‘behavior’, ‘neuroprotection’, ‘neurodegenerative diseases’, and ‘mechanisms’ as search words.
It highlights its influences on behavioral patterns of anxiety, aggression, depression, memory, psychotic, and stress. The molecular mechanisms such as modulation of the antioxidant defense, inflammatory biomarkers, neurotransmitter regulation, and neuronal regeneration, underlying its actions in managing neurodegenerative diseases like Alzheimer’s and Parkinson’s diseases are also discussed.
This review, therefore, provides a detailed evaluation of methyl jasmonate as a potential neuroprotective compound with the ability to modify behavioral and molecular biomarkers underlying neurological disorders. Hence, MJ modelled as a guided treatment for the management of brain diseases.
Keywords: Methyl jasmonate, Neuroprotection, Neurodegenerative diseases, anxiety, depression


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