miR-132 AND miR-942 EXPRESSION LEVELS IN CHILDREN WITH ATTENTION DEFICIT AND HYPERACTIVITY DISORDER: A CONTROLLED STUDY
SEYMA COSKUN 1, MEHMET KARADAG 2*, CEM GOKCEN 2, SERDAR OZTUZCU 3
1Child and Adolescent Psychiatry Clinic, Adana, Turkey, 2Gaziantep University Medical School Child and Adolescent Psychiatry Department, Gaziantep, Turkey, 3Gaziantep University Medical School Medical Biology and Genetic Department, Gaziantep, Turkey
Received: June 4, 2020; Revised: October 15, 2020; Accepted: October 16, 2020; Published online: October 16, 2020.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: Although attention deficit hyperactivity disorder (ADHD) is a disease with high genetic transition, our knowledge about the mechanism of the disease is limited. In this study, it was aimed to evaluate the levels of miR-132-3p and miR-942-5p that are associated with the dopamine carrier protein gene (DAT1) and dopamine receptor 5 (DRD5) genes, which have been shown to play a role in the development of ADHD.
Methods: According to DSM-5, 50 children diagnosed with ADHD and 48 healthy controls were included in the study. Affective Disorders and Schizophrenia Interview Schedule-Now and Lifetime Version - Turkish Adaptation (K-SADS-PL-T) was used to evaluate ADHD and the diagnoses accompanying ADHD. Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) was used to evaluate miR-132-3p and miR-942-5p expression levels.
Results: It was observed that miR-132-3p level (p = 0.001) was significantly higher with children with ADHD compared to the control group, and the level of miR-942-5p (p = 0.181) was higher in ADHD but did not reach statistically significant level.
Conclusions: In our study, we found that the increase in the miR-132-3p levels of children with ADHD may be a therapeutic target of the disease.
Keywords: Attention deficit hyperactivity disorder, microRNA, miR-132-3p, miR-942-5p, children genetic


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