A DIFFERENT VIEW ON ETIOPATHOGENESIS OF ATTENTION DEFICIT HYPERACTIVITY DISORDER FROM INFLAMMATION PERSPECTIVE
semiha dursun 1, esra demirci 1, eser kılıç 2, sevgi özmen 1*
1Department of Child and Adolescent Psychiatry,Erciyes University School of Medicine, Kayseri, Turkey, 2Department of Biochemistry, Erciyes University School of Medicine, Kayseri, Turkey
Received: May 21, 2020; Revised: August 26, 2020; Accepted: September 30, 2020; Published online: September 30, 2020.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: Attention-deficit hyperactivity disorder (ADHD) has a complex etiology and genetic, environmental and biological factors are considered to play a role in the etiology of ADHD by mutually interacting. Recent studies have emphasized that inflammation may be present in the etiology of ADHD. This study aims to investigate the possible role of visfatin, IL-6, IL-1β and TNF-α molecules in the etiology of ADHD.
Method: The study included 60 patients and 20 healthy controls between the ages of 6-18. Serum visfatin, IL-6, IL-1β and TNF-α levels were evaluated with enzyme-linked immunosorbent assay (ELISA) kits at a biochemistry laboratory.
Results:The study showed no statistically significant difference between children with ADHD and healthy controls in terms of visfatin, IL-6, IL-1β and TNF-α levels. When ADHD subgroups (combined and predominantly inattentive types) and the control group were compared in terms of visfatin, IL-6, IL-1β and TNF-α levels no statistically significant difference was recorded.
Conclusion: Data on the relationship between ADHD and IL-6, IL-1β and TNF-α in this study is in compliance with literature. However, no study was found on visfatin in ADHD. This study is the first one evaluating the ADHD-Visfatin relationship.
Keywords: Attention deficit hyperactivity disorder, IL-1β, IL-6, inflammation, TNF-α, visfatin


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