Autism-like behaviors in male juvenile offspring after maternal glyphosate exposure
Yaoyu Pu 1, Li Ma 1, Jiajing Shan 1, Xiayun Wan 1, Bruce D Hammock 2, Kenji Hashimoto 1*
1Chiba University Center for Forensic Mental Health, 2University of California, Davis
Received: September 14, 2020; Accepted: September 25, 2020; Published online: September 25, 2020.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: Exposure to the herbicide glyphosate during pregnancy and lactation may increase the risk for autism spectrum disorder (ASD) in offspring. Recently, we reported that maternal exposure of formulated glyphosate caused ASD-like behaviors in juvenile offspring. Here, we investigated whether maternal exposure of pure glyphosate could cause ASD-like behaviors in juvenile offspring.
Methods: Water or 0.098% glyphosate was administered as drinking water from E5 to P21 (weaning). Behavioral tests such as grooming test and three-chamber social interaction test in male offspring were performed from P28 to P35.
Results: Male offspring showed ASD-like behavioral abnormalities (i.e., increasing grooming behavior and social interaction deficit) after maternal exposure of glyphosate.
Conclusion: The findings suggest that the exposure of glyphosate during pregnancy and lactation may cause ASD-like behavioral abnormalities in male juvenile offspring. It is likely that glyphosate itself, but not the other ingredients, may contribute to ASD-like behavioral abnormalities in juvenile offspring.
Keywords: autism, ingredient, glyphosate, maternal exposure, offspring


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