Elevated monocyte to high-density lipoprotein ratios as an inflammation markers for schizophrenia patients
Musa Sahpolat 1, 1, 1, Duygu Ayar 2, 2, 2, Mustafa Ari 3, 3, 3*, Mehmet Akif Karaman 4, 4, 4
1Department of Psychiatry, Kilis State Hospital, Kilis, Turkey, 2Yusuf Serefoglu Faculty of Health Sciences, Kilis 7 Aralık University, Kilis, Turkey, 3Department of Psychiatry, Mustafa Kemal University Tayfur Ata Sokmen Faculty of Medicine, Hatay, Turkey, 4Department of Psychological Counseling and Guidance, Kilis 7 Aralık University, Kilis, Turkey
Received: March 27, 2020; Revised: May 30, 2020; Accepted: June 8, 2020; Published online: June 8, 2020.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: Monocyte to high density lipoprotein ratio (MHR) is a new instrument for giving notice inflammation, which plays a main role in schizophrenia. Thus, in this study, our goal was to investigate the possible association between MHR and schizophrenia.
Methods: The participants of this study consisted of 75 schizophrenia patients and 74 healthy individuals (control group). The Positive and Negative Syndrome Scale (PANSS) was used to collect data from the patient group. Complete blood count parameters and lipid profile were analyzed in all study participants.
Results: The patients with schizophrenia had higher MHR values (15.04±3.31 in schizophrenia patients and 12.62±2.99 in controls; p=0.001). Monocyte counts and MHR of the schizophrenia patients were significantly higher than the control group. There was a significant and positive correlation between age, BMI, severity of disease and MHR.
Conclusion: To our knowledge, this study was the first to demonstrate inflammatory markers such as MHR levels in schizophrenia patients. Both monocyte counts and MHR values in schizophrenia patients were higher than the control group. MHR might be an available and useful inflammatory marker to evaluate inflammation in schizophrenia patients.
Keywords: high density lipoprotein, inflammation, monocyte, schizophrenia


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