A Randomized Controlled Trial to Compare the Efficacy, Safety and Tolerability of Asenapine versus Olanzapine in Management of Schizophrenia
Arpita Maitra 1, Swati Bhattacharyya 2*, Sabyasachi Mukhopadhyay 3, Asim Kumar Mallick 1, Supreeti Biswas 1, Om Prakash Singh 1
1Burdwan Medical College, 2R G Kar Medical College, 3AMRI Hospital, Kolkata
Received: March 20, 2020; Revised: May 14, 2020; Accepted: May 17, 2020; Published online: May 17, 2020.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Objective: Schizophrenia is a serious disease characterized by impairment in the perception or expression of reality, leading to occupational and social dysfunction. The use of antipsychotic medication is now universal in the first-line treatment of schizophrenia. This study was undertaken to compare the efficacy of asenapine with a standard atypical antipsychotic, olanzapine in treating this disease.
Method: It was designed as a single blind, randomized, controlled, parallel group, single centre Phase IV trial of a newer atypical antipsychotic, asenapine versus existing standard atypical antipsychotic, olanzapine. Total 80 subjects were enrolled as per eligibility criteria.Each recruited subject received daily treatment with the trial medication (Olanzapine 10 mg or Asenapine 10mg daily) for duration of 12 weeks. BPRS, CGI-S, CGI-I, Laboratory parameters and compliance was assessed and analyzed. Continuous variables were compared by t-test and non-parametric data was analyzed by Mann Whitney U test and Wilcoxon signed rank test. Likely categorical variables were analyzed by chi-square test or Fisher’s exact test, as appropriate.
Results: The duration of schizophrenia at presentation was comparable in both the treatment groups. There was significant reduction of BPRS score between any two visits of each treatment groups. The decline in CGI-S and CGI-I scores was statistically significant (p<0.001) when compared between visits of any of the both treatment arms. Adherence to treatment was excellent for all patients.
Conclusions: Newer atypical antipsychotic asenapine is more effective than standard olanzapine in reducing the symptoms of schizophrenia in this study and further larger studies are to be done.
Keywords: Schizophrenia, Antipsychotic, Asenapine, Olanzapine