Vitamin D supplement is beneficial to autism spectrum disorder: a meta analysis
Liyao Song 1, Xiaomei Luo 1, Qin Jiang 1, Zhi Chen 2, Lifang Zhou 1, Dan Wang 1, Ai Chen 1*
1Department of Pediatric, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, 646000, China;, 2Standardized training nurse, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, 646000, China;
Received: August 14, 2019; Revised: December 2, 2019; Accepted: December 2, 2019; Published online: December 2, 2019.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: we conducted a meta-analysis of randomized controlled trials (RCT) to explore whether vitamin D supplements beneficial to the symptom improvement of children with an autism spectrum disorder (ASD).
Methods: We systematically searched the PubMed database, EMBASE, Cochrane Library, Web of Science, Sino Med, WANFANG DATA and CNKI mainly up to September 2019. The standard mean difference (SMD) with 95% confidence interval (CI) was calculated using a fixed effect model. The baseline serum levels of 25(OH) D and the outcome scores included Social Responsiveness Scale scores and Child Autism Rating scores after vitamin D supplementation were analyzed.
Results: The difference of baseline serum 25(OH) D levels in included 203 children from three studies in the meta-analysis was not statistically significant. By vitamin D supplementation, the outcome scores included Social Responsiveness Scale (SRS) and Child Autism Rating scores (CARS) in the experimental group were dramatically elevated comparing to the control group (p=0.03).
Conclusion: Vitamin D supplementation was beneficial to children with autism by improving their typical symptoms which illustrated by the reduced scores of Social Responsiveness Scale and Child Autism Rating scores.
Keywords: vitamin D, Children, Autism spectrum disorders, Meta-analysis


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