Clinical Psychopharmacology and Neuroscience 2019; 17(4): 503-508  
Difference in Cognitive Function by First Onset Age of Alcohol Induced Blackout and Its Duration
Eun-Jeong Min1, Sung-Gon Kim1,2, Jin-Seong Lee1,2, Bia Seo1, Woo-Young Jung1, Sung-Young Huh1, Ji-Hun Park3, Chang-Hee Hong4, Hee Jung Yu5
1Department of Psychiatry, Pusan National University Yangsan Hospital, 2Department of Psychiatry, Pusan National University School of Medicine, Yangsan, 3Park Ji Hun Neuropsychiatry, 4Department of Psychology, Pusan National University, 5Department of Social Welfare & Counseling, Catholic University of Pusan, Busan, Korea
Correspondence to: Sung-Gon Kim
Department of Psychiatry, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20 Geumo-ro, Mulgeum-eup, Yangsan 50612, Korea
E-mail: sungkim@pusan.ac.kr
ORCID: https://orcid.org/0000-0001-7566-941X
*The findings from this study were presented at 16th International Society of Addiction Medicine Annual Meeting, October 2−6, 2014, Yokohama, Japan.
Received: December 26, 2018; Revised: February 26, 2019; Accepted: May 1, 2019; Published online: November 30, 2019.
© The Korean College of Neuropsychopharmacology. All rights reserved.

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objective: Alcohol-induced blackout (blackout) is a typical early symptom of cognitive impairment caused by drinking. However, the first onset age of blackout or the duration after onset of blackout has not been directly compared in previous studies. The purpose of this study was to investigate the differences in cognitive function to the first start age of blackouts and their duration.
Methods: Thirty-one male subjects were included in this study. Their age at the first blackout and the duration after the onset of blackout were investigated. Neuropsychological tests were conducted to determine their attention, memory, and executive function. Subjects were divided into three groups according to their age of the first onset blackout (group O1, < 20 years; group O2, 21−39 years; and group O3, > 40 years). Subjects were also divided into three groups by duration after the onset of blackout (P1, < 10 years; P2, 10−29 years; and P3, > 30 years). We then examined differences in neurocognitive function among these groups.
Results: O1 tended to have a lower memory score than O2 (F = 3.28, p = 0.053). Significant differences were observed in attention and executive function between groups P1 and P3 (Digit Span_backward: F = 6.07, p < 0.05; visual span_forward: F = 4.19, p < 0.05; executive intelligence quotient: F = 3.55, p < 0.05).
Conclusion: Greater memory impairment was detected in subjects having an earlier age of the first blackout. The longer the duration after the onset of blackout, the more impaired their attention and executive function skills.
Keywords: Alcohol-induced blackout; Alcohol-induced disorder; Retrograde amnesia; Cognition; Addiction medicine.


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