Clinical Psychopharmacology and Neuroscience 2018; 16(3): 324-332  https://doi.org/10.9758/cpn.2018.16.3.324
Neural Signature for Auditory Hallucinations in Schizophrenia: A High-Resolution Positron Emission Tomography Study with Fludeoxyglucose (18F)
Jong-Hoon Kim1,2, Young Don Son3, Jeong-Hee Kim4, Hyo-Jong Lee5, Nam-In Kang6, Gyung Ho Chung7,8, Jong-Il Park7,9, Yin Cui7,9, Woo-Sung Kim7,9, and Young-Chul Chung7,9
1Department of Psychiatry, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea, 2Neuroscience Research Institute, Gachon University, Incheon, Korea, 3Department of Biomedical Engineering, Gachon University, Incheon, Korea, 4Research Institute for Advanced Industrial Technology, Korea University, Sejong, Korea, 5Department of Computer Science and Engineering & Center for Advanced Image and Information Technology, Chonbuk National University, Jeonju, Korea, 6Department of Psychiatry, Maeumsarang Hospital, Wanju, Korea, 7Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea, 8Department of Radiology, Chonbuk National University Medical School, Jeonju, Korea, 9Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Korea
Correspondence to: Young-Chul Chung, MD, PhD, Department of Psychiatry, Chonbuk National University Medical School, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea, Tel: +82-63-250-2185, Fax: +82-63-275-3157, E-mail: chungyc@jbnu.ac.kr, ORCID: https://orcid.org/0000-0001-9491-1822
Received: January 26, 2018; Revised: April 6, 2018; Accepted: April 23, 2018; Published online: August 31, 2018.
© The Korean College of Neuropsychopharmacology. All rights reserved.

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

Objective

Auditory hallucinations (AHs) are a core symptom of schizophrenia. We investigated the neural signature of AHs by comparing hallucinating patients with schizophrenia with non-hallucinating patients with schizophrenia.

Methods

We recruited hallucinating patients with schizophrenia meeting the criteria for persistent, prominent, and predominant AHs (n=10) and non-hallucinating patients with schizophrenia (n=12). Various clinical assessments were performed incluing Psychotic Symptom Rating Scale for Auditory Hallucinations. Using fludeoxyglucose (18F) positron emission tomography, regional differences in neural activity between the groups were analyzed.

Results

The regions of interest analysis showed significantly lower standardized uptake value ratio (SUVR) in the superior, middle, and inferior frontal gyri, and higher SUVR in the putamen in patients with AHs versus patients without AHs. These findings were confirmed in the voxel-wise analysis.

Conclusion

Our findings indicate that hypoactivity in the frontal and cingulate gyri, coupled with hyperactivity in the temporal gyrus and putamen, may contribute to the pathophysiology of AHs.

Keywords: Auditory hallucinations, Schizophrenia, Positron-emission tomography, Bottom-up, Top-down
INTRODUCTION

Auditory hallucinations (AHs) occur in the general population at a median estimated rate of 4% to 5%.1) In patients with schizophrenia, the prevalence is quite common, up to 74%.2) Moreover, 25% to 50% of subjects continue to experience them despite medication.3,4) The experience of voices can impact on quality of life, self-esteem, anxiety, depression, suicide attempts, and cognitive function.57) Determining the pathophysiological basis of AHs is important for understanding the neurobiological processes underlying schizophrenia and for the development of more effective treatment strategies for patients who are unresponsive to existing therapies. Despite extensive research, little is known about the neurobiology underlying this phenomenon.

Over recent decades, neuroimaging research has attempted to determine the neural mechanism(s) involved in the development of AHs in patients with schizophrenia. Volumetric studies have consistently reported that severity of AHs is associated with reduced relative volume in the left auditory cortex, left amygdala, left insula, and prefrontal cortex.810) In parallel, functional neuroimaging studies have uncovered various areas associated with AHs. In a meta-analysis, it was reported that hallucinators showed increased activation likelihoods in a distributed bilateral frontotemporal network that included Broca’s area, the anterior insula, the precentral gyrus, the frontal operculum, middle and superior temporal gyri, the inferior parietal lobule, the hippocampus, and the parahippocampal region.11) Results from the meta-analysis supported two hypotheses: (1) aberrant activation within frontal-temporal language areas during AH and (2) dysfunction in the verbal memory system that could lead to the occurrence of AH.

To capture the neurobiological underpinnings of AHs directly, it is important to recruit patients with prominent and persistent AHs and to distinguish on- and off-set of AHs within an imaging session. Several functional magnetic resonance imaging (fMRI) studies used a button-pressing approach1214) and a random-sampling method15) to capture brain processes directly involved in generating AHs. However, the scanner noise generated during fMRI procedures can activate the auditory cortex and mask neural activity due to AHs. Positron emission tomography (PET) imaging is a relatively quiet process despite its lower spatial and temporal resolution versus fMRI. Only two reported PET studies selected homogeneous patients with prominent and frequent AHs16,17) and checked for the occurrence of AHs during the scanning process.16) They reported higher metabolic rates in the left superior and middle temporal cortices, bilateral superior medial frontal cortex, and left caudate nucleus16) and in the right middle frontal gyrus (Brodmann area 46)17) in patients with AHs versus non-hallucinating patients. Problems with those studies included that the time duration of AHs during the scanning process was not provided.

Comparing the neural activities in schizophrenic patients with AHs with those in normal controls would produce findings related not only to the neural correlates of AHs but also to disease-related neural correlates. Therefore, we thought that comparison between patients with AHs and without AHs would uncover distinctive neural correlates of AHs by avoiding the confounding effects of disease-related symptomatology other than AHs. This study was undertaken to investigate regional differences in neural activity between patients with and without AHs and to explore relationships between glucose metabolism and severity of AHs using high-resolution fludeoxyglucose (18F) ([18F]FDG)-PET.

METHODS

Participants

We recruited 10 patients with schizophrenia reporting persistent, prominent, and predominant AHs and 12 age- and gender-matched patients with schizophrenia reporting no AHs at least for the past 3 months or no experience of AHs ever. Patients were screened at Chonbuk National University Hospital in Jeonju, Korea. Diagnoses were established using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID).18) The characteristics of AHs were defined as follows: persistent as sustained over the past 3 months, prominent as occurring ≥10 times/day and 3 days/week, and predominant as Positive and Negative Syndrome Scale (PANSS)19) P1 score ≤3 (mild) and P3 score ≥4 (moderate). Exclusion criteria were alcohol or drug abuse within the last 6 months, claustrophobia, history of head trauma, other neurological disorders, pregnancy, and significant medical problems.

This study was approved by the ethical committees of Chonbuk National University Hospital (approval number: 2012-07-014) and Gachon University Gil Medical Center (approval number: GIRBD0027-2012) where the PET and MRI scans were performed. All participants gave oral and written informed consent after the objectives and procedures of the study had been explained.

Assessment

Within 1 week before PET imaging, psychopathology was evaluated by experienced psychiatrists using the PANSS, Calgary Depression Scale for Schizophrenia (CDSS),20) and Social and Occupational Functioning Assessment Scale.21) The Prospective and Retrospective Memory Questionnaire (PRMQ)22) was also used to measure the level of cognitive functioning. The scores of the prospective and retrospective subscales of the PRMQ were calculated by summing the scores of items 1, 3, 5, 7, 10, 12, 14, and 16, and the rest of the items, respectively. On the day of PET imaging, the Psychotic Symptom Rating Scale for Auditory Hallucinations (PSYRATS-AH)23) was used before the [18F]FDG injection. All participants were right-handed. The 11 items of the PSYRATS-AH assess different dimensions of AHs and can be clustered in three factors: a physical characteristics factor (frequency, duration, location, and loudness), an emotional characteristics factor (amount and degree of negative content and of distress), and a cognitive interpretation factor (disruption, belief about origin, and attribution of control).

Acquisition and Reconstruction of PET and MRI Data

All patients were scanned with a high-resolution research tomograph (HRRT)-PET (Siemens, Knoxville, TN, USA) and a 7-T MRI (Magnetom; Siemens, Erlangen, Germany). The HRRT-PET is an ultra-high-resolution brain-dedicated PET scanner that has a transaxial in-plane resolution of 2.5-mm full width at half maximum (FWHM).24,25) All patients fasted for at least 6 hours before [18F]FDG PET scanning. A bolus injection of [18F]FDG (injected dose, 192.5±12.6 MBq) was administered intravenously. During uptake of [18F]FDG into the brain, patients were seated on a bed for 30 minutes. During [18F]FDG uptake, all patients measured the duration of AHs themselves using a stopwatch. After [18F]FDG uptake, an emission scan was performed in static scan mode for 30 minutes. After the emission scan, a transmission scan was conducted for 6 minutes 10 seconds using a 137Cs point source for attenuation correction. After [18F]FDG PET scans, 7-T MRI was scanned using a three-dimensional T1-weighted magnetization-prepared rapid gradient echo (3D T1MPRAGE) sequence for structural brain imaging. 3D T1MPRAGE images were acquired with the following parameters: repetition time (TR)=1,900 ms, echo time (TE)=3.73 ms, inversion time (TI)=1,100 ms, flip angle=10°, voxel size=0.75×0.75×0.75 mm3, and number of slices=256.

PET images were reconstructed using the 3D-ordinary Poisson ordered-subset expectation maximization (OP-OSEM3D) algorithm that was accelerated using symmetry and single-instruction multiple-data-based projection and back-projection techniques.26) The reconstructed PET images were post-processed with decay correction and had a matrix of 256×256×207 and iso-voxel resolution of 1.22×1.22×1.22 mm3. For the calculation of the [18F]FDG standardized uptake value ratio (SUVR), the [18F]FDG PET emission data were reconstructed as a single frame.

Data Processing and Statistical Analysis

None of the patients with AHs was excluded because they all experienced AHs during the 30 minutes of [18F]FDG uptake. Images were inspected visually for motion artifacts by an expert in PET image quality assurance. Spatial preprocessing and statistical analyses of the PET images were performed in Statistical Parametric Mapping 8 (SPM8; Wellcome Trust Centre for Neuroimaging, UK; http://www.fil.ion.ucl.ac.uk/spm). For spatial preprocessing, each patient’s PET image was coregistered to the same patient’s MRI image. Then, all MRI images with coregistered PET images were spatially normalized into the Montreal Neurological Institute (MNI) template used in SPM8. Finally, spatially normalized PET images were smoothed with a Gaussian kernel of 6-mm FWHM. To calculate [18F]FDG SUVR values, the intensity value of each voxel in the PET image was divided by the mean intensity of all intracerebral voxels.27) The [18F]FDG SUVR values were obtained in 116 predefined regions of interest (ROIs) using the automated anatomical labeling (AAL) program.28)

Demographic and clinical data were compared between the groups using two-tailed t test or chi-square test. To compare regional glucose metabolism between the groups, we performed ROI-based analyses and voxel-based analyses. For the ROI-based analyses, 90 ROIs, excluding the cerebellum and vermis, were selected based on a literature review.29) A two-tailed p value <0.05 was considered to indicate a statistically significant value. In the voxel-based analysis, the level of statistical significance was set as p<0.005, uncorrected, with a minimum cluster size of 20 adjacent voxels. Between-group comparisons on regional [18F]FDG SUVR values were performed using a two-tailed t test or analysis of covariance (ANCOVA), as appropriate. The correlations between the [18F]FDG SUVR values and the severity of AHs assessed using PSYRATS-AH in patients with AHs were not analyzed because of small sample size. In ROI-based analysis, a two-tailed probability value of p<0.05 was chosen as a statistically significant value. In voxel-based analysis, the level of statistical significance was defined as p<0.005 uncorrected with a minimum cluster size of 20 adjacent voxels. To correct for multiple comparisons, results were further analyzed using thresholds of family wise error (FWE) and false discovery rate (FDR) at p<0.05.

RESULTS

Demographic and clinical data of patients with AHs (AH group) and without AHs (non-AH group) are summarized in Table 1. Significant differences between the groups were observed in the CDSS, chlorpromazine equivalence, PANSS total and –positive subscale total, PSYRATS-AH, and PRMQ retrospective subscale. For the PANSS subscales, only the positive scale score was significantly different between the groups (p=0.002). The durations (second) of AHs that occurred in the [18F]FDG uptake were 787.64±684.48 (range, 48.55–1,742.21) and 0 for the AH and non-AH groups, respectively.

As for the results on group differences, the ROI analysis demonstrated significantly lower SUVR in the orbital parts of right middle and inferior frontal gyri and medial parts of the superior frontal gyrus and higher SUVR in the left and right putamen in patients with AHs versus patients without AHs (Table 2). However, when controlled for the confounding factors (the CDSS, PRMQ retrospective sub-scale, and chlorpromazine-equivalent doses), no finding remained significant. The voxel-based analysis revealed greater activation in the left middle and inferior temporal gyri, left putamen, left and right fusiform gyri, and left cerebellum (p<0.005, uncorrected) and less activation in the left superior, middle, and inferior frontal gyri, right inferior frontal gyrus, left precentral gyrus, and left and right middle cingulate gyri (p<0.005, uncorrected) in the AH group versus the non-AH group (Table 3, Fig. 1). When corrected for the confounding factors including age and multiple comparisons, these findings were no longer significant.

DISCUSSION

To determine the neural basis of AHs, we compared SUVR between patients with and without AHs and investigated correlations between SUVR and severity of AHs using [18F]FDG-PET. To enhance the homogeneity of the AHs, characteristics for persistent, prominent, and predominant AHs were clearly predefined. In the AH group, we observed hyperactivity in the putamen and temporal gyrus, and hypoactivity in several parts of the frontal gyrus and cingulate gyrus compared with the non-AH group. These findings support a neurocognitive model in which both bottom-up and top-down processes interact to produce these erroneous percepts.29,30)

With regard to the results of frontal activity, implicated in the pathogenesis of AHs, several studies have reported hyperactivity in the right medial prefrontal gyrus,31) medial and superior frontal gyri,32) middle and superior frontal gyri,16) and the frontal operculum.11) However, hypo-activity has also been reported in the left premotor cortex33) and bilateral superior frontal gyrus.34) In the present study, we observed hypoactivity in the superior, middle, and inferior frontal gyri in both ROI and voxel-based analyses (albeit at an uncorrected level). Hypoactivity has been demonstrated in trait studies33,34) comparing patients experiencing AHs with patients without AHs or healthy controls during tasks with verbal material or auditory stimuli. That is, they investigated the neural bases of the susceptibility to hallucinate, independent of the subjects’ experience during scanning. As our study did not use a task during [18F]FDG uptake and all subjects in the AH group experienced AHs during uptake, our results may reflect direct measures of brain activation associated with AHs. In this regard, this is the first reported study demonstrating hypoactivity in the frontal areas as a neural mechanism of AHs. However, it should be noted that our findings may be associated with depression in patients with AHs, not with AHs per se, because the score of the CDSS was significantly higher in patient with AHs compared to patients without AHs and positive findings were disappeared when controlling for depression. A recent meta-analysis on the changes of brain activity in depression reported that in resting condition, increased correlated activity was observed in the left amygdala, left para-hippocampus, left claustrum, left putamen, right thalamus, and right posterior cerebellum and decreased activity was shown in the left superior temporal, right anterior cingulate, and left middle frontal regions under resting conditions.35) In future study, it would be critical to recruit participants without depression or groups without difference in depression severity. Nontheless, implications of the findings may be as follows. The superior frontal gyrus is thought to contribute to higher cognitive functions, such as working memory,36) task-switching,37) and self-focused reappraisal.38) The middle frontal gyrus is important in reorienting attention to an exogenous stimulus39) and the right inferior frontal gyrus is important for inhibition40) and hierarchical organization.41,42) Assuming that both too much and too little are not good, abnormal activity in a certain brain area, regardless of direction, indicates impaired function in that area. Thus, our finding of hypoactivity in the frontal gyrus can be interpreted as indicating that, in the AH group, there may be impaired higher cognitive function, which may, in turn, cause a weakening of top-down control. This suggestion may be supported partially by the finding that the score of the PRMQ retrospective subscale in the AH group was significantly higher than in the non-AH group, indicating greater memory impairment. The anterior cingulate cortex plays a central role in the self-monitoring that is necessary for adaptive goal-directed behavior43) and in exerting attentional control and selection for action.44) We observed hypoactivity (decreased glucose metabolism) in the middle cingulate gyrus in the AH group, consistent with other studies.33,45) Hyperactivity in the cingulate cortex15,31,32,46) has also been reported. Again, these abnormal activities in the cingulate gyrus/cortex may result in defective self-monitoring, causing impairment in top-down control.

The AH group showed increased activity in the putamen by ROI analysis. In voxel-based analysis, this was expanded to the middle and inferior temporal gyri, fusiform gyrus, and cerebellum. The result of increased activity in the putamen was rather unexpected in that it has classically been considered to be primarily a motor structure47,48). The activation may have been caused by hand movement in measuring the time duration of AHs. Arguments against this interpretation are that we observed bilateral activation of the putamen (although only left putamen in the voxel-based analysis) and some studies reported increased activation in the left caudate nucleus16) and left basal ganglia,49) and decreased activity in the lenticular nucleus,50) in which there was no hand movement to signal on- and off-set of AHs. An alternative explanation may be that given the role of the putamen in syntactic processing of sentence comprehension,51) contents of AHs experienced in the AH group may contain syntactic errors. This needs to be investigated further in future studies. We observed significantly higher activation in the left middle and inferior temporal gyri in the AH group versus the non-AH group. Increased activity in the temporal lobe is the finding most frequently and consistently reported, especially in activity studies directly measuring brain activity occurring during the experience of hallucinations.29) However, in trait studies that measured functional activity during auditory stimulation tasks, decreased activation of the temporal gyrus was observed.52) This seemingly opposite phenomenon has been called a ‘paradoxical effect’,52) suggesting a kind of ‘competition for neuronal resources’ between internally and externally generated neuronal activity. The middle temporal gyrus is known to be involved in several cognitive processes, including language and semantic memory processing53) and perceiving inner speech.54,55) The inferior temporal gyrus is associated with visual perception.56) Thus, our results suggest that internally generated overrepresentations, stemming from abnormal processing in language/speech and visual stimuli, may be implicated in the pathogenesis of AHs. This concept differs from the previous theories explaining AHs, such as overactivation of the auditory cortex,57) and misattribution of internally generated speech,58,59) which all involve the superior temporal gyrus. Taken together, our findings suggest that overrepresentations or errors in language/speech caused by hyperactivity in the middle temporal gyrus or putamen in addition to defective monitoring or top-down control related to the cingulate gyrus or frontal gyrus may contribute to the pathophysiology of AHs.

The current study has some limitations. First, there was no healthy control group, which may limit the interpretation of our findings. However, the comparison between patients with and without AHs has the advantage of distinguishing AH-specific neural activities from disease-related effects. Second, given that most of the positive findings disappeared when controlling for confounding variables, it cannot be ruled out that our findings may be due to differences in depression, medication doses, and memory functioning. Third, we could not extend our positive findings with a threshold of pFWE-corrected and pFDR-corrected data. Despite these shortcomings, strengths of the present study are that we recruited homogeneous patients meeting the criteria for persistent, prominent, and predominant AHs and included only subjects experiencing AHs during [18F]FDG uptake period. Additionally, compared with conventional PET scanners, the HRRT-PET system used in our study has been reported to increase the accuracy of the quantification of glucose metabolism in brain regions due to decreased partial-volume effects.60) In conclusion, our findings suggest that hypoactivity in the frontal and cingulate gyri, coupled with hyperactivity in the temporal gyrus and putamen, may contribute to the pathophysiology of AHs.

Acknowledgments

This study was supported by the Fund of the Biomedical Research Institute, Chonbuk National University Hospital. For Jong-Hoon Kim, this work was supported by the Brain Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT, and Future Planning (2016M3C7A1914451).

Figures
Fig. 1. Statistical parametric maps showing group differences: greater activation in the temporal gyrus and the putamen and lesser activation in the frontal and cingulate gyri in the auditory hallucinations (AHs) group compared to the non-AHs group (cluster size=20, p<0.005, uncorrected). MNI, the Montreal Neurological Institute template.
Tables

Demographic and clinical characteristics of the participants

VariableSchizophreniap value

With AHs (n=10)Without AHs (n=12)
Age (yr)39.20±10.5531.00±9.09<0.064
Education (yr)14.00±1.8913.83±1.99<0.843
Married state, single/married/divorced8/1/18/2/2<1.000
Sex, male/female7/38/4<1.000
Age of onset (yr)26.80±9.4420.08±7.81<0.082
CDSS8.00±5.443.50±4.08<0.038*
Chlorpromazine equivalence (mg/day)856.00±654.17340.42±285.49<0.023*
Duration of illness (mo)136.20±76.07112.50±78.01<0.481
PANSS total51.10±9.8640.92±9.09<0.020*
PRMQ
 Prospective17.30±4.9014.83±6.39<0.330
 Retrospective18.30±6.313.00±4.86<0.039*
PSYRATS-AH
 Total24.50±6.472.08±7.22<0.001*
 Physical characteristics9.10±1.450.67±2.31<0.001*
 Emotional characteristics8.80±4.760.92±3.18<0.001*
 Cognitive interpretation6.60±1.900.50±1.73<0.001*
SOFAS59.00±10.7566.67±11.93<0.132

Values are presented as mean±standard deviation or number only.

AHs, auditory hallucinations; CDSS, Calgary Depression Scale for Schizophrenia; PANSS, Positive and Negative Syndrome Scale; PRMQ, Prospective and Retrospective Memory Questionnaire; PSYRATS-AH, Psychotic Symptom Rating Scales-Auditory Hallucinations; SOFAS, Social and Occupational Functioning Assessment Scale.

*Statistically significant.

ROI analysis demonstrating regional differences in SUVR values between the groups

Brain regionSchizophreniap value*

With AHs (n=10)Without AHs (n=12)
Orbital part of right inferior frontal gyrus2.51±0.142.70±0.250.044
Orbital part of right middle frontal gyrus2.71±0.142.92±0.290.044
Medial part of superior frontal gyrus2.50±0.142.70±0.280.047
Left putamen3.38±0.233.17±0.220.048
Right putamen3.37±0.213.15±0.250.038

Values are presented as mean±standard deviation.

ROI, region of interest; SUVR, standardized uptake value ratio; AHs, auditory hallucinations.

*Analyzed by t test.

Group differences in standardized uptake value ratio*

Cluster locationCluster-level statisticsVoxel-level statisticsPeak coordinates (MNI)Peak location



pFWEkp, unc.pFWEpFDRtzp, unc.x, y, z (mm)
AHs >non-AHs
 Left cerebellum anterior lobe1.000200.2830.9740.7364.903.93<0.001−14, −52, −22Left cerebellum_4_5/left cerebellum_6
 Left temporal lobe0.992380.1450.9930.7364.723.82<0.001−40, −44, −6Left middle temporal gyrus (BA19)
1.0000.7364.023.40<0.001−50, −48, −2Left middle temporal gyrus (BA20)
 Right limbic lobe1.000210.2720.9990.7364.543.72<0.00140, −18, −34Right fusiform gyrus (BA21)
 Left inferior temporal gyrus0.983430.1220.9990.7364.523.71<0.001−40, −2, −32Left middle temporal gyrus/left inferior temporal gyrus
1.0000.7364.373.62<0.001−34, −2, −40Left fusiform gyrus (BA20)
 Left fusiform gyrus1.000250.2321.0000.7364.313.58<0.001−40, −42, −24Left cerebellum 6/left fusiform gyrus
 Left sub-lobar/Left lentiform nucleus0.972470.1081.0000.7364.133.47<0.001−30, 0, 6Left putamen
AHs
 Left middle frontal gyrus1.000220.2610.9460.9985.044.00<0.001−46, 8, 42Left middle frontal gyrus/left precentral gyrus (BA6)
 Left inferior frontal gyrus1.000200.2830.9960.9984.663.79<0.001−30, 24, −24Orbital part of left inferior frontal gyrus (BA47)
 Left middle frontal gyrus1.000210.2721.0000.9984.383.62<0.001−32, 56, −4Orbital part of left middle frontal gyrus/orbital part of left superior frontal gyrus/left superior frontal gyrus (BA10)
 Right inferior frontal gyrus1.000200.2831.0000.9984.363.61<0.00128, 24, −28Orbital part of right inferior frontal gyrus (BA47)
 Right cingulate gyrus0.993370.1501.0000.9984.323.59<0.0012, −28, 32Left middle cingulate gyrus/right middle cingulate gyrus

MNI, the Montreal Neurological Institute template; AHs, auditory hallucinations; FWE, family wise error; FDR, false discovery rate; k, number of adjacent voxels per cluster; unc., uncorrected; BA, Brodmann area.

*Thresholded at p≤0.001, uncorrected, cluster size ≥20 voxels.

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